Basic Information
VIS ID
TVIS10009458
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
650
Orient
-
Integrated sequence
CTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTG| |GGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATG
Host Sequence
Chromosome
chr4
Cytoband
q34.1
Reference genome
GRCh37/hg19
Start
174630355/173709204 (Hg38)
End
174630355/173709204 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/440971; hsa-mir-1305/Downstream/714591;
Nearest TSS
ENST00000502981/Upstream/150050; ENST00000509968/Downstream/188048;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/170301, chr4-CpG: 21/Downstream/504904
Nearby gene
HAND2-AS1(-167374) ; FBXO8(+527455) ;
Upstream sequence
gagtgtgttctaccaacctctactgcagttctccacagtccccatgatgagcatcctttctccctgcatgtgcagtaaacacaacttaatcagccacagg
Downstream sequence
cctgaccttgtgatccgcccgcctcggcctcccaaagtgctgggattacaggcgtgagccacctcacccagccAAGCCTACATCTTTACAAATATTATAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate