VISDB Viral Integration Site DataBase

VIS ID

TVIS10009464

Fusion event

HBV-CYP3A5 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2474

Orient

+

Integrated sequence

GAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGG| |TGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTAT

Chromosome

chr7

Cytoband

q22.1

Reference genome

Start

End

99273134/99675511 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-3191-5p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-6728-3p ; hsa-mir-4438

Nearest miRNA

hsa-mir-10525/Upstream/266247; hsa-mir-10399/Downstream/418049;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/58249, chr7-CpG: 76/Downstream/243468

Upstream sequence

tttattttttttttattgatcattcttgggtgtttctcgcagagggggatttggcagggtcataggacaatagtggagggaaggtcagcagataaacaag

Downstream sequence

CTGCTACTGGCCTTCTGGACATGAGCTTGTGACTTTCCCTCCAGGGGTAAACCTGGCCATGCTTTGGGTGGAGCCTACACACCTTTtcctctcctctcct