Basic Information
VIS ID
TVIS10009467
Fusion event
HBV-LINC02603 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1782
Orient
-
Integrated sequence
TGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGG| |CTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGT
Host Sequence
Chromosome
chr9
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
96988121/94225839 (Hg38)
End
96988121/94225839 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC02603
Nearest miRNA
hsa-let-7a-1/Upstream/46919; hsa-mir-12126/Downstream/584123;
Nearest TSS
ENST00000422679/Upstream/21271; ENST00000492115/Downstream/33472;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/58660, chr9-CpG: 41/Downstream/33343
Nearby gene
LINC02603(-21273) ; ZNF169(+33457) ;
Upstream sequence
CTGGGTTGATGGGCCCACAGTAGCTAGCACCTGTTTCTGCTTCCAAGCAGACTCTGTTAGCCAACCCAGTGCAGGCTCACATCCACTAAGATGTAACTGT
Downstream sequence
ctttaagagctgtaacactcactgtgaaggtctgcagctgcattcctgaagtcggccagaccatgaacccgctggaaggaaccaactctggacacactgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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