Basic Information
VIS ID
TVIS10009471
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
257
Orient
+
Integrated sequence
TGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTC| |GTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCA
Host Sequence
Chromosome
chrX
Cytoband
p22.31
Reference genome
GRCh37/hg19
Start
9016002/9047961 (Hg38)
End
9016002/9047961 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3690-1/Upstream/920900; hsa-let-7f-2/Downstream/2270653;
Nearest TSS
ENST00000429181/Upstream/13834; ENST00000432442/Downstream/115240;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/246443, chrX-CpG: 22/Downstream/294717
Nearby gene
FAM9B(-14886) ; TBL1X(+415333) ;
Upstream sequence
cattagtgggtgcagcgcaccagcatggcacatgtatacatatgtaactaacctgcacaatgtgcacatgtaccctaaaacttagagtataataaaaaaa
Downstream sequence
caccatactgaaagcccatcagccattctcacccggaaaattccttattagaatctttacatatttccggggcctgcccttactctataaagaatctttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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