Basic Information
VIS ID
TVIS10009477
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
-
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
105428312/104885690 (Hg38)
End
105428312/104885690 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4604382; hsa-mir-11399/Downstream/3011533;
Nearest TSS
ENST00000473358/Upstream/1135284; ENST00000635102/Downstream/720313;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1359399, chr1-CpG: 37/Downstream/1195081
Nearby gene
LOC100129138(-808619) ;
Upstream sequence
tttgcatttatctgatgattactgatgttgagcattttttcctatgcttgttggctccatgtatgtctttttttgataagtgtttgttaatgtactttgc
Downstream sequence
ccattttttttttttttttttttttttttttttttttttttgagacggagtctcgctctgtcgcccaggctggagtgcagtggcgggatctcggctcact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate