Basic Information
VIS ID
TVIS10009482
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
162
Orient
+
Integrated sequence
TGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAG| |AACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGT
Host Sequence
Chromosome
chr1
Cytoband
q22
Reference genome
GRCh37/hg19
Start
155548496/155578705 (Hg38)
End
155548496/155578705 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/232260; hsa-mir-1182/Downstream/372568;
Nearest TSS
ENST00000473358/Upstream/15898; ENST00000471209/Downstream/31500;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/15216, chr1-CpG: 52/Downstream/31236
Nearby gene
ASH1L-AS1(-14761) ; MSTO1(+31465) ;
Upstream sequence
gttcacgccattctcctgcctcagcctcccgagtagctgggactacaggcgcccgccaccgcgcccggctaattttttgtatttttagtagagatggggt
Downstream sequence
ttcaccgtgttagccaagatggtctcgatctcctgaccttgtgatccgcccgcctcggcctcccaaagtgctgggattacaggcgtgagccaccgcgccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate