Basic Information
VIS ID
TVIS10009494
Fusion event
HBV-DEPDC1-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
73
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCA| |GTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATC
Host Sequence
Chromosome
chr1
Cytoband
p31.2
Reference genome
GRCh37/hg19
Start
68970934/68505251 (Hg38)
End
68970934/68505251 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
DEPDC1-AS1
Nearest miRNA
hsa-mir-101-1/Upstream/321641; hsa-mir-11399/Downstream/2562380;
Nearest TSS
ENST00000473358/Upstream/8030; ENST00000646352/Downstream/128450;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/7928, chr1-CpG: 131/Downstream/1062033
Nearby gene
DEPDC1(-8135) ; LRRC7(+1254924) ;
Upstream sequence
tgaaactatttttttttttttttttttttttttgagacggagtctcgctctgtcgcccaggccggactgcggactgcagtggcgcaatctcggctcactg
Downstream sequence
caagctccgcctcccaggttcacgccattctcctgcctcagcctcccgagtagctgggactacaggcgcccgccaccgcgcccggctaattttttgtatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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