Basic Information
VIS ID
TVIS10009496
Fusion event
HBV-CCDC186 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
-
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chr10
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
115897800/114138041 (Hg38)
End
115897800/114138041 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
CCDC186
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-2110 ; hsa-mir-25-3p ; hsa-let-7b-5p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-107/Upstream/359987; hsa-mir-202/Downstream/36064;
Nearest TSS
ENST00000439456/Upstream/5947; ENST00000369280/Downstream/6561;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/36707, chr10-CpG: 26/Downstream/35579
Upstream sequence
caggagaatcacttgaacccaggaggcggaggttgcggtgagccgaaattgcgccactgtactccagcctgggcaacaagagtgaaactcggtctcaaaa
Downstream sequence
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaataaaaaaaatacacaaattagccaggcatggtggtgggcacctgtaatcccagctactcgggaggctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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