Basic Information
VIS ID
TVIS10009518
Fusion event
HBV-TRIM49C integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
22
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAA| |CTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTC
Host Sequence
Chromosome
chr11
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
89789199/90056031 (Hg38)
End
89789199/90056031 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRIM49C
miRNAs that regulate target gene
hsa-mir-500a-3p
Nearest miRNA
hsa-mir-10392/Upstream/1879438; hsa-let-7a-2/Downstream/499743;
Nearest TSS
ENST00000527297/Upstream/24925; ENST00000530464/Downstream/29919;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2243, chr11-CpG: 65/Downstream/166543
Nearby gene
TRIM49C(-14006) ; UBTFL1(+29919) ;
Upstream sequence
TTTCCATTCTCTGTCATCTGGAttcttttttttttttttttttttgagacggagtcccgctctttagcccaggccggattgcagtggcacaatcttggct
Downstream sequence
cactgcaagctccgcctcccaggttcacgccattctcctgcctcagcctcccgagtagctgggactacaggcgcccgccaccgcgcccggctaatttttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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