VISDB Viral Integration Site DataBase

VIS ID

TVIS10009524

Fusion event

HBV-PLEKHA5 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1936

Orient

-

Integrated sequence

CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC

Chromosome

chr12

Cytoband

p12.3

Reference genome

Start

End

19520193/19367259 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-25-3p ; hsa-mir-218-5p

Nearest miRNA

hsa-mir-1244-3/Upstream/1693865; hsa-let-7i/Downstream/4845162;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/60488, chr12-CpG: 147/Downstream/71990

Upstream sequence

acaggcataagccaccatgcccggccCTTTTACTCTTTTTCTTTATGATTTTTTGGGAACAGGGATGGGAATTAGTGCATATTATCGCTTTGCTTCttct

Downstream sequence

ttttttttttttttttttttttttgaagctctttcacccaggctggagtgatgtggcgtgatctcagctcactgcaatctccacctcccaggttcaagcg