Basic Information
VIS ID
TVIS10009531
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
599
Orient
+
Integrated sequence
CAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCAC| |CTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAG
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
83966200/83572421 (Hg38)
End
83966200/83572421 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/2413960; hsa-mir-1178/Downstream/3172647;
Nearest TSS
ENST00000382841/Upstream/400831; ENST00000642846/Downstream/89298;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/884554, chr12-CpG: 17/Downstream/1339000
Nearby gene
TMTC2(-438133) ; SLC6A15(+1287067) ;
Upstream sequence
CTGGGACATGTTCCATATTGCACAAACTAAATTATTTACATCAAATGGCTACAGTGGGAGGTGAGTTCTTATTTCACTGAGTTTCCTTCTCTGTAGTATT
Downstream sequence
CACGGTTTTTCAATTTTGGTCACTGTGATTATATATGTTTCCTCGTGCTTTTTTTGCTTGTTCTTAAACTTCTTCTCTTGCCTATAGTTTTCAAGAAAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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