Basic Information
VIS ID
TVIS10009533
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
28
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGC| |AAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTT
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
91235617/90841840 (Hg38)
End
91235617/90841840 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/4096691; hsa-mir-1178/Downstream/3719949;
Nearest TSS
ENST00000382841/Upstream/32564; ENST00000546725/Downstream/76183;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1131552, chr12-CpG: 30/Downstream/112187
Nearby gene
ATP2B1-AS1(-1129888) ; LINC00615(+76183) ;
Upstream sequence
AGGTTGGGGGACACTATGATGAGCAATTATGAGCCAGGGGTTGTCTTCATAGTAACATCATTACATCCTTCACAGCCTAAAAAAATCTCTCCCATTTggc
Downstream sequence
tgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgaggcgggcggatcacaaggtcaggagatcgagaccatcttggctaacacggtga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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