VISDB Viral Integration Site DataBase

VIS ID

TVIS10009545

Fusion event

HBV-chr15 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1829

Orient

+

Integrated sequence

GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT

Chromosome

chr15

Cytoband

q26.1

Reference genome

Start

End

90454143/89910911 (Hg38)

Orient

+

Location type

Intronic

Target gene

ARPIN ; ARPIN-AP3S2

miRNAs that regulate target gene

hsa-mir-6807-5p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-6751-3p ; hsa-mir-769-5p ; hsa-mir-1199-5p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-4302 ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-4293 ; hsa-mir-449b-3p ; hsa-mir-508-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-6862-5p ; hsa-mir-3945 ; hsa-mir-4253 ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-4716-5p ; hsa-mir-3607-5p ; hsa-mir-4735-3p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-548m ; hsa-mir-4786-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-1247-3p ; hsa-mir-1247-3p ; hsa-mir-1292-3p ; hsa-mir-140-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-194-3p ; hsa-mir-2467-3p ; hsa-mir-2467-3p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-3612 ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-377-5p ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-4257 ; hsa-mir-4453 ; hsa-mir-4537 ; hsa-mir-4538 ; hsa-mir-455-3p ; hsa-mir-455-3p ; hsa-mir-4640-5p ; hsa-mir-4726-5p ; hsa-mir-500a-3p ; hsa-mir-5186 ; hsa-mir-6086 ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-6499-3p ; hsa-mir-6508-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-6516-5p ; hsa-mir-6828-5p ; hsa-mir-767-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-1273e ; hsa-mir-4537 ; hsa-mir-5186 ; hsa-mir-6807-5p

Nearest miRNA

hsa-mir-10393/Upstream/26881; hsa-mir-1302-10/Downstream/95844;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/16549, chr15-CpG: 70/Downstream/1419

Upstream sequence

CATTTCCCCTGGGGATGAAAGGGAAAGAAAGGATAGCCAGTTTTGTCAGTCCTCAGCAAATCTCACCCGTGTCTCCTATTTACCCAGCCCTGAGAAGGCT

Downstream sequence

GGGTACTGAGCAGCTCCTTTCCCCGTGCTTCCGACATAGGGATCTCCAAAGGGTCCCAAAGGCTGGGGCATTGCCCAGATGCCAGGAGGAACCTTgtcag