Basic Information
VIS ID
TVIS10009549
Fusion event
HBV-LOC105371275 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
168
Orient
+
Integrated sequence
CTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATC| |ACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTT
Host Sequence
Chromosome
chr16
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
54926584/54892672 (Hg38)
End
54926584/54892672 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105371275
Nearest miRNA
hsa-mir-1225/Upstream/4150295; hsa-mir-11401/Downstream/1352848;
Nearest TSS
ENST00000527434/Upstream/18504; ENST00000560154/Downstream/27944;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/600881, chr16-CpG: 479/Downstream/35838
Nearby gene
IRX3(-606206) ; CRNDE(+26193) ;
Upstream sequence
ATTTATTCCAAAACACTTATGTATCTAGTTTTGAAAAATAATAATTTCggctgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgagg
Downstream sequence
cgggcggatcacaaggtcaggagatcgagaccatcttggctaacacggtgaaaccccgtctctactaaaaatacaaaaaattagccgggcgcggtggcgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate