Basic Information
VIS ID
TVIS10009555
Fusion event
HBV-BCO1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1930
Orient
-
Integrated sequence
CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG| |GAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGA
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
81313883/81280278 (Hg38)
End
81313883/81280278 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16D
Target gene
BCO1
Nearest miRNA
hsa-mir-1225/Upstream/4411259; hsa-mir-11401/Downstream/104740;
Nearest TSS
ENST00000527434/Upstream/41587; ENST00000567335/Downstream/33145;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/183665, chr16-CpG: 141/Downstream/34467
Upstream sequence
attgaacctgggaggcagaggttgcggtaagccaagatcacaccactgcactccggactccagtctgggcaacagagtgagactccatctcaaaaaaaaa
Downstream sequence
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaattacacacacacacagacacacacacacacacacacacacacatttagtatatttctctgtctcttctcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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