VISDB Viral Integration Site DataBase

VIS ID

TVIS10009556

Fusion event

HBV-COTL1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

523

Orient

+

Integrated sequence

TGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGA| |CCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTG

Chromosome

chr16

Cytoband

q24.1

Reference genome

Start

End

84639274/84605668 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-1-3p ; hsa-mir-744-5p ; hsa-mir-331-3p ; hsa-mir-320a ; hsa-mir-506-3p ; hsa-mir-1205 ; hsa-mir-1273h-3p ; hsa-mir-127-3p ; hsa-mir-1286 ; hsa-mir-147a ; hsa-mir-3166 ; hsa-mir-3169 ; hsa-mir-3612 ; hsa-mir-3911 ; hsa-mir-3936 ; hsa-mir-4418 ; hsa-mir-4459 ; hsa-mir-449b-3p ; hsa-mir-4695-5p ; hsa-mir-4722-5p ; hsa-mir-4740-5p ; hsa-mir-4755-3p ; hsa-mir-4771 ; hsa-mir-4786-3p ; hsa-mir-5006-5p ; hsa-mir-501-5p ; hsa-mir-509-3-5p ; hsa-mir-509-5p ; hsa-mir-548ad-3p ; hsa-mir-6124 ; hsa-mir-644a ; hsa-mir-650 ; hsa-mir-6890-3p ; hsa-mir-7843-3p ; hsa-mir-873-5p

Nearest miRNA

hsa-mir-1225/Upstream/1097260; hsa-mir-11401/Downstream/602128;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/100159, chr16-CpG: 119/Downstream/11686

Upstream sequence

gaagggtggggaagagggccagaaccagagagctggcatcatgaggactcgacctgccagtactggctttgaagacagaggaagtggccacaagccaaag

Downstream sequence

aatgcaggcagtctctggaagcacaagaaggcaagaaaatggattctcccctggagcctccaggagaaagcagccctgtccacacctggattttagtcct