VISDB Viral Integration Site DataBase

VIS ID

TVIS10009568

Fusion event

HBV-BRCA1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

116

Orient

-

Integrated sequence

ACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTT| |ATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTC

Chromosome

chr17

Cytoband

q21.31

Reference genome

Start

End

41230407/43078390 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-146a-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-212-3p ; hsa-mir-24-3p ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-99b-3p ; hsa-mir-484 ; hsa-mir-186-5p ; hsa-mir-181a-5p ; hsa-mir-20b-5p ; hsa-mir-498 ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-4726-3p ; hsa-mir-1297 ; hsa-mir-6872-3p ; hsa-mir-125a-3p ; hsa-mir-34a-5p ; hsa-mir-483-3p ; hsa-mir-10b-5p

Nearest miRNA

hsa-mir-1180/Upstream/254447; hsa-mir-10226/Downstream/366416;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/52814, chr17-CpG: 24/Downstream/47727

Nearest cancer related gene

BRCA1(TSG, No orient, 0)

Upstream sequence

gccaggctggtcttaaactcctgacctcaggtgatccgccaaccttggcctcacaaagtgctgggattataggcatgagccaccatacccagcctggtct

Downstream sequence

agaactcttaaactcaagtgatcctcctgccttggcatctcacagtgctgggattataggcgtgagccaccatgcctggccAAGGCGGAAATATTTAATA