Basic Information
VIS ID
TVIS10009572
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1814
Orient
-
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
10231/10231 (Hg38)
End
10231/10231 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Downstream/102025;
Nearest TSS
ENST00000575820/Downstream/872;
Nearest CpG islands
None/Target, None/Upstream, chr18-CpG: 67/Downstream/1477
Nearby gene
ROCK1P1(+98834) ;
Upstream sequence
ccctaaccctaacccttaaccctaacccttaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccccaaccccaaccccaaccctaacc
Downstream sequence
cctaacccctaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaccctaaccctaccctaccctaaccctaaccctaaccctaacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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