Basic Information
VIS ID
TVIS10009576
Fusion event
HBV-TUBB8P12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1814
Orient
-
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
63689/63689 (Hg38)
End
63689/63689 (Hg38)
Orient
-
Location type
Intronic
Target gene
TUBB8P12
Nearest miRNA
hsa-mir-1-2/Downstream/48567;
Nearest TSS
ENST00000575820/Upstream/14132; ENST00000580410/Downstream/9828;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/14034, chr18-CpG: 51/Downstream/9373
Nearby gene
ROCK1P1(+45376) ;
Upstream sequence
ggctaccATATAACTTTATTAAAagccctagccctagccctaaccctaaccccaaaccctaaccctagccctagccttagccctaaccctaaccctaacc
Downstream sequence
cctaaccctaaccctaaccctaacactaaccctaacccctaaccctaactctaaccctaaccctagccctaaccctaaccctagccctagccttagccct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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