Basic Information
VIS ID
TVIS10009585
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1028
Orient
+
Integrated sequence
ACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCT| |TTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTA
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
23064091/22881289 (Hg38)
End
23064091/22881289 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/2481935; hsa-let-7e/Downstream/12241411;
Nearest TSS
ENST00000633603/Upstream/48968; ENST00000594318/Downstream/33000;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/73440, chr19-CpG: 40/Downstream/12514
Nearby gene
ZNF99(-97118) ; ZNF728(+93594) ;
Upstream sequence
atctgggctcactgcaacctccgcctctggggttcaagcaattctcctgcctcagcctcccacccaagtagctgggattataggcaggcactgccatgct
Downstream sequence
tgtgtaattttttttttttttttttttttaagtagagacagggtttcaccatgttggccaggctggtttcaaactcctgacctcaagtgatctgctcacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate