Basic Information
VIS ID
TVIS10009590
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
30
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAA| |GATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCT
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
104956052/104339594 (Hg38)
End
104956052/104339594 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/1907228; hsa-mir-10b/Downstream/4801896;
Nearest TSS
ENST00000437798/Upstream/192365; ENST00000416008/Downstream/71607;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1602639, chr2-CpG: 44/Downstream/319536
Nearby gene
TMEM182(-1521914) ; LOC100287010(+39256) ;
Upstream sequence
aacataacatctaccctcttagcaaacttttttttttttttttttgaggctaagtctcgctctgtcgcccaggttggagtgcagtggcgcgatctcggct
Downstream sequence
cactgcaagctccgcctcccaggttcacgccattctcctgcctcagcctcccgagtagctgggactacaggcgcccgccaccgcgcccgactaatttttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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