Basic Information
VIS ID
TVIS10009593
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
-
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
111277865/110520288 (Hg38)
End
111277865/110520288 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
RGPD5 ; RGPD6
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/235345; hsa-mir-10b/Downstream/800725;
Nearest TSS
ENST00000437798/Upstream/47213; ENST00000458252/Downstream/10842;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/96258, chr2-CpG: 99/Downstream/56091
Upstream sequence
catgtttgatgtcttttcccactcttgttttttgtttctcccatgctgaattccgtgtaatttcttttgaaccatcttgtagtttacattcttttttttt
Downstream sequence
ttttttatttttttttttttttttttttttttttgagataggagttttgctcttgttgcttgggctggagtgcaatggcaccatctcggctcactgcaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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