VISDB Viral Integration Site DataBase

VIS ID

TVIS10009594

Fusion event

HBV-CYP27C1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1936

Orient

-

Integrated sequence

CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC

Chromosome

chr2

Cytoband

q14.3

Reference genome

Start

End

127968939/127211363 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-1273h-3p ; hsa-mir-376b-3p ; hsa-mir-376a-3p ; hsa-mir-4771 ; hsa-mir-3166 ; hsa-mir-3158-5p ; hsa-mir-1304-3p ; hsa-mir-6890-3p ; hsa-mir-7705 ; hsa-mir-6854-5p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-129-5p ; hsa-mir-5089-5p ; hsa-mir-6807-5p ; hsa-mir-6881-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-874-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-4749-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-6078 ; hsa-mir-877-3p ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-6887-3p ; hsa-mir-6504-3p ; hsa-mir-4438 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-1299 ; hsa-mir-7107-3p ; hsa-mir-6753-3p ; hsa-mir-6503-5p ; hsa-mir-4527 ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-3663-5p ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-4732-3p ; hsa-mir-4716-5p ; hsa-mir-4781-3p

Nearest miRNA

hsa-mir-1285-2/Upstream/13489995; hsa-mir-10b/Downstream/212174;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/103651, chr2-CpG: 148/Downstream/7450

Nearby gene

CYP27C1(-5596) ; ERCC3(+45927) ;

Upstream sequence

taaataatgaaattaaagcagaaatcaagaagttctttgaaaccaatgagaacaaagagacaacgtaccagaatctctgggatacagctaaagcagtgtt

Downstream sequence

tttttgtttttttttttttttttttttttttttttttgagatggagtctcgctctttcacccaggctggactgcagtggcgctatcttggctcactgcaa