TTN _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009596
Fusion event
HBV-TTN integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
36
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCC| |AGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGA
Host Sequence
Chromosome
chr2
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
179564297/178699570 (Hg38)
End
179564297/178699570 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
TTN
miRNAs that regulate target gene
hsa-mir-26a-5p ; hsa-mir-144-3p
Nearest miRNA
hsa-mir-10b/Upstream/1385688; hsa-mir-1244-1/Downstream/1161266;
Nearest TSS
ENST00000437798/Upstream/27152; ENST00000590024/Downstream/2950;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/218540, chr2-CpG: 112/Downstream/564321
Upstream sequence
gcgcaatctcggctcactgcaagctccgcctcccaggtccacaccattctcctgcctcagcctcccgagtagctgggactacaggcgcccgccaccgcgc
Downstream sequence
ccggctaattttttgtatttttagtagagacggggtttcaccgtgttagccaagatggtctcgatctcctgaccttgtgatccgcccgcctcggcctccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate