VISDB Viral Integration Site DataBase

VIS ID

TVIS10009601

Fusion event

HBV-MACROD2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1823

Orient

-

Integrated sequence

TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA

Chromosome

chr20

Cytoband

p12.1

Reference genome

Start

End

15004453/15023807 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-4469 ; hsa-mir-486-5p ; hsa-mir-660-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-618 ; hsa-mir-502-5p ; hsa-mir-4786-3p ; hsa-mir-1915-5p ; hsa-mir-6841-3p ; hsa-mir-153-5p ; hsa-mir-6808-3p ; hsa-mir-7973 ; hsa-mir-486-3p ; hsa-mir-4252 ; hsa-mir-4725-5p ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-504-5p

Nearest miRNA

hsa-mir-103a-2/Upstream/4374112; hsa-mir-1-1/Downstream/3446808;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/1027385, chr20-CpG: 50/Downstream/1549384

Upstream sequence

aaaacagcatgggaaagacctgtccccatgattcaattacttcccatagattcgctcctatgacgtgggaattctgggggctgcaattcaagatgagatt

Downstream sequence

tgggtgggaacacagccaaaccgtatcaCCCAAGGAACACATCAGTGATCACTTCTCACACATTTTCACTGGAGCACACAGGCTGAActccatgaactgt