VISDB Viral Integration Site DataBase

VIS ID

TVIS10009603

Fusion event

HBV-XKR7 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|Polymerase|

Start

1554

Orient

-

Integrated sequence

GACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGT| |CTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTA

Chromosome

chr20

Cytoband

q11.21

Reference genome

Start

End

30564095/31976292 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-874-3p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-3649 ; hsa-mir-146b-3p ; hsa-mir-6799-3p ; hsa-mir-7976 ; hsa-mir-3173-5p ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-6859-3p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-764 ; hsa-mir-660-5p ; hsa-mir-137 ; hsa-mir-367-3p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-363-3p ; hsa-mir-5186 ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-624-5p ; hsa-mir-590-3p ; hsa-mir-374b-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-6124 ; hsa-mir-1252-5p ; hsa-mir-646 ; hsa-mir-922 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-651-3p ; hsa-mir-3180-5p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-4267 ; hsa-mir-1207-3p

Nearest miRNA

hsa-mir-103a-2/Upstream/369052; hsa-mir-1-1/Downstream/261503;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/7593, chr20-CpG: 32/Downstream/18693

Upstream sequence

ggcacagagaagagtggccttccaattcataaggagcaaagctagggtttgaagccatgaggtcaggctcccaaacccacatgtggaaccaccaaactat

Downstream sequence

actgtCTTCTGCTAGTTAAGTGTATTCTTACAAACAATCAATCATGTATTGTTTAGAGAAGCAGAAGAAAAAATATCAGAAAAGTAtttttatttttttt