VISDB Viral Integration Site DataBase

VIS ID

TVIS10009606

Fusion event

HBV-PCK1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

115

Orient

+

Integrated sequence

CACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCT| |TATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTT

Chromosome

chr20

Cytoband

q13.31

Reference genome

Start

End

56139933/57564877 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-33b-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-627-3p ; hsa-mir-330-3p ; hsa-mir-7151-5p ; hsa-mir-3163 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-8064 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-26a-1-3p ; hsa-mir-129-5p ; hsa-mir-1297 ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-3650 ; hsa-mir-4465 ; hsa-mir-5697

Nearest miRNA

hsa-mir-103a-2/Upstream/243286; hsa-mir-1-1/Downstream/1252738;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/39683, chr20-CpG: 39/Downstream/87319

Upstream sequence

ACCAACCCTTCTGGTCACCTGGAACCTTTCTGAATCCCTGATCTATTGTAGCTTGATCAAATTTTACTTTTTACTTTGTGGCCTCAGTCATGTAACTTTG

Downstream sequence

AGTTAGCAGTTTTCTGCAATTTAGCTTGGTGAACGCAAAACTAGCTCGATTACAAAGTTATTGTCTTGCCGTGTCTTTCCGTGTTGTGAATAACACCACT