Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009609
Fusion event
HBV-SH3BGR integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
66
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGT| |GGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACA
Host Sequence
Chromosome
chr21
Cytoband
q22.2
Reference genome
Start
End
40882012/39510085 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-let-7c/Upstream/63016; hsa-mir-3197/Downstream/702267;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/64038, chr21-CpG: 49/Downstream/102597
Upstream sequence
aggccggattgcagtggcgcaatctcggctcactgcaagctccgcctcccaggttcacgccattctcctgcctcagcctcccgagtagctgggactacag
Downstream sequence
gcgcccgccaccgcgcccggctaattttttgtatttttagtagagacggggtttcaccgtgttagccaagatggtctcgatctcctgaccttgtgatccg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.