Basic Information
VIS ID
TVIS10009620
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1039
Orient
+
Integrated sequence
AAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATG| |TGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTG
Host Sequence
Chromosome
chr3
Cytoband
q26.33
Reference genome
GRCh37/hg19
Start
182645896/182928108 (Hg38)
End
182645896/182928108 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA3C
Nearest miRNA
hsa-let-7g/Upstream/6412957; hsa-mir-1224/Downstream/958692;
Nearest TSS
ENST00000440867/Upstream/6170; ENST00000471731/Downstream/52043;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/133614, chr3-CpG: 91/Downstream/51853
Nearby gene
ATP11B(-6475) ; DCUN1D1(+14663) ;
Nearest cancer related gene
DCUN1D1(OG, +14663) ;
Upstream sequence
GCAAATATACTGAGATTACAACTTTCCTTCCAGTTGAAGGATGACATCAGCAGCTTTATAGTGGAAACACTTTAACTTCTCAGGAATAAGTGATCTGATC
Downstream sequence
aTaaaacctcccaacaaagaaaagcccaggaacaagatgacttcactggagaattctaccaaacatttaaaaattaacaccaatcatcttcaaactcttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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