Basic Information
VIS ID
TVIS10009622
Fusion event
HBV-LOC105374280 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
104
Orient
+
Integrated sequence
CCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTAC| |TGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAG
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
192955954/193238165 (Hg38)
End
192955954/193238165 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374280
Nearest miRNA
hsa-let-7g/Upstream/3408156; hsa-mir-3137/Downstream/1896341;
Nearest TSS
ENST00000440867/Upstream/61301; ENST00000264735/Downstream/2960;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/319987, chr3-CpG: 84/Downstream/2755
Nearby gene
MB21D2(-320004) ; PLAAT1(+2963) ;
Upstream sequence
tactttatctcagttaatagtaccatgctccatccttcactagctagaatattagtatcattttcattttctcactttcccatccccacatggcattagt
Downstream sequence
aagctgaggctcagaggtttaacaaacatgcttcttatcatacagctagcaaatggtagaaccaggcttagaacccaagactcatgactcattgcctttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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