Basic Information
VIS ID
TVIS10009630
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1814
Orient
-
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
10098/10098 (Hg38)
End
10098/10098 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Downstream/340059;
Nearest TSS
ENST00000502981/Downstream/43187;
Nearest CpG islands
None/Target, None/Upstream, chr4-CpG: 46/Downstream/43206
Nearby gene
ZNF595(+43129) ;
Upstream sequence
aggcaggagaatggcgtgaacccgggaggcggagcttgcagtgagccgagatcgcgccactgcactccagcctgggcgacagagcgagactccgtctcac
Downstream sequence
ccctaaccctaaccctaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaacgctaaccctaaccctaaccctaaccctaaccctc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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