Basic Information
VIS ID
TVIS10009638
Fusion event
HBV-LOC105374510 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
598
Orient
+
Integrated sequence
ACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCA| |CCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCA
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
18491766/18490143 (Hg38)
End
18491766/18490143 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC105374510
Nearest miRNA
hsa-mir-12113/Upstream/4862186; hsa-mir-12115/Downstream/2038132;
Nearest TSS
ENST00000502981/Upstream/635; ENST00000511431/Downstream/965293;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/467493, chr4-CpG: 284/Downstream/1761510
Nearby gene
LCORL(-468283) ; SLIT2(+1763469) ;
Upstream sequence
CAGTAAAATAAAGTTTTAGTAAACTCTGCATCTTTAAAGAATTATTTTGGCATTTATTTCTAAAATGGCATAGTATTTTGTATTTGTGAAGTCTTACAAG
Downstream sequence
cagcaatctttgctgttctgtatcctccactggtgataaccaggcgaacaaggtcgggggagtggaactccagcaaactgctgcagaactgcagaagagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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