VISDB Viral Integration Site DataBase

VIS ID

TVIS10009642

Fusion event

HBV-APBB2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

136

Orient

+

Integrated sequence

AGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGA| |TTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCAC

Chromosome

chr4

Cytoband

p14

Reference genome

Start

End

40925168/40923151 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-424-5p ; hsa-mir-93-5p ; hsa-mir-27a-3p ; hsa-mir-1260b ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-3915 ; hsa-mir-526b-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-3663-3p ; hsa-mir-4638-3p ; hsa-mir-3690 ; hsa-mir-942-3p

Nearest miRNA

hsa-mir-12113/Upstream/421032; hsa-mir-1243/Downstream/6729518;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/65861, chr4-CpG: 95/Downstream/290703

Upstream sequence

AAGTCATTGCAGTACAACAACATTTACTGTTTACAAACAGTCATATAGCAATTCAGTTAAAAGTTTTATAAATTGTTTGATTTTATAAATAGGATTATTT

Downstream sequence

tttttagtagagacggggtttcaccgtgttagccaagatggtctcgatctcctgaccttgtgatccgcccgcctcggcctcccaaagtgctgggattaca