Basic Information
VIS ID
TVIS10009644
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1943
Orient
+
Integrated sequence
TCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGA| |GTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCAT
Host Sequence
Chromosome
chr4
Cytoband
p13
Reference genome
GRCh37/hg19
Start
43179535/43177518 (Hg38)
End
43179535/43177518 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/2675399; hsa-mir-1243/Downstream/4475151;
Nearest TSS
ENST00000502981/Upstream/43651; ENST00000507639/Downstream/315025;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/519985, chr4-CpG: 174/Downstream/1269851
Nearby gene
GRXCR1(-146860) ; KCTD8(+996385) ;
Upstream sequence
AAGTGTCccaatatcttaacggcaagctgaaaaaccaggaccacagccacctgctagtttgctcttgaattcctgtcctacagaaattgtgagattaaaa
Downstream sequence
ttgaacagaaccaccatcaaaccaaactgacccagccaagatcggtaatctcctagctgacaattcacctaccagggagcccagctgagactagtaaaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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