Basic Information
VIS ID
TVIS10009645
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1516
Orient
-
Integrated sequence
CGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACC| |GACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGA
Host Sequence
Chromosome
chr4
Cytoband
p13
Reference genome
GRCh37/hg19
Start
43198570/43196553 (Hg38)
End
43198570/43196553 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/2694434; hsa-mir-1243/Downstream/4456116;
Nearest TSS
ENST00000502981/Upstream/62686; ENST00000507639/Downstream/295990;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/539020, chr4-CpG: 174/Downstream/1250816
Nearby gene
GRXCR1(-165895) ; KCTD8(+977350) ;
Upstream sequence
aatatcttaacggcaagctgaaaaaccaggaccacagccacctgctagtttgctcttgaattcctgtcctacagaaattgtgagattaaaaaaaaaaaaa
Downstream sequence
tgtgttcctggtggtctttgattggaCTTTGCTCTTTAGACAATTATACTAAAGTTAGTTCTATGACTGTGTTATTTGAAACTTTGAGTTGGAGAGTAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate