Basic Information
VIS ID
TVIS10009677
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
57
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTC| |CCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACA
Host Sequence
Chromosome
chr5
Cytoband
p12
Reference genome
GRCh37/hg19
Start
43033265/43033163 (Hg38)
End
43033265/43033163 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374748 ; LOC648987
Nearest miRNA
hsa-mir-10397/Upstream/4475602; hsa-mir-103a-1/Downstream/10918341;
Nearest TSS
ENST00000502646/Upstream/14680; ENST00000607830/Downstream/553;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/14597, chr5-CpG: 22/Downstream/3994
Nearby gene
LOC648987(-14352) ; ANXA2R(+5917) ;
Upstream sequence
TATCATTCCTTCCTCCACAGGAGTGAGAGGAACTCCTCTGCCCCTGGGGGGGGATAGGGAAGGGGCTCAATCCCAGTAGAGTAGGAGGGATGGACTTTAA
Downstream sequence
ccgccaccgcgcccggctaattttttgtatttttagtagagacggggtttcaccgtgttagccaagatggtctcgatctcctgaccttgtgatccgcccg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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