Basic Information
VIS ID
TVIS10009681
Fusion event
HBV-LINC02056 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
-
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
71902930/72607103 (Hg38)
End
71902930/72607103 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02056
Nearest miRNA
hsa-mir-10397/Upstream/437563; hsa-mir-103a-1/Downstream/271488;
Nearest TSS
ENST00000502646/Upstream/26126; ENST00000515483/Downstream/53566;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/146305, chr5-CpG: 110/Downstream/209227
Nearby gene
ZNF366(-99681) ; TNPO1(+209488) ;
Upstream sequence
TGAGATTACGAGTGATTGTGTAAACCCAGGCCTGAAGTTATACTTTATTAAGGTAAATCATGCTGATTTTCAGCTTTCACTGAAGATTTACCTTTTCCTT
Downstream sequence
caaaaaaaaaaaaaaaaaaaaaaaaaaaaaaacaaaaaaaaaaaccaaaaaaggtgcagagattttattagttgaagtacctgaatgaaagaaataggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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