Basic Information
VIS ID
TVIS10009688
Fusion event
HBV-CMAHP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
103
Orient
+
Integrated sequence
TCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTA| |CTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACA
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
25126607/25126379 (Hg38)
End
25126607/25126379 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
CMAHP
Nearest miRNA
hsa-mir-3691/Upstream/6554499; hsa-mir-10398/Downstream/2021247;
Nearest TSS
ENST00000381078/Upstream/69306; ENST00000461945/Downstream/152699;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/215021, chr6-CpG: 36/Downstream/13313
Upstream sequence
ATGACTAAAAAGAGAAATGCTTCCCAAACTACTTAAGTATCTTAGAACAATTTTAATTAAGTATGGTTTATTAAGCTACTAAACATCCAGCCAGATAGGT
Downstream sequence
tagccgggcgcggtggcgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacctgggaggcggagcttgcagtgagccgag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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