VISDB Viral Integration Site DataBase

VIS ID

TVIS10009695

Fusion event

HBV-TMEM178B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

99

Orient

+

Integrated sequence

AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTG| |ACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGT

Chromosome

chr7

Cytoband

q34

Reference genome

Start

End

141113974/141414174 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-606 ; hsa-mir-8485 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7113-5p ; hsa-mir-508-5p ; hsa-mir-432-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-3189-3p ; hsa-mir-212-5p ; hsa-mir-216b-5p ; hsa-mir-216a-5p ; hsa-mir-494-3p ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-22-3p ; hsa-mir-574-3p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-6867-3p ; hsa-mir-7111-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4268 ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6787-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-3922-5p ; hsa-mir-541-3p ; hsa-mir-15a-3p ; hsa-mir-4432 ; hsa-mir-4717-5p ; hsa-mir-4803 ; hsa-mir-499a-5p ; hsa-mir-5684 ; hsa-mir-5704 ; hsa-mir-645 ; hsa-mir-8087 ; hsa-mir-298 ; hsa-mir-3158-5p

Nearest miRNA

hsa-mir-10399/Upstream/2370017; hsa-mir-11400/Downstream/1060353;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/339414, chr7-CpG: 59/Downstream/137039

Upstream sequence

TTTTATTTGTTATTATTTGAACCTTGTTCACCTAACGGCTAACAATCTCCTAACTAATATATCCAgaaaaccattggagggttttgaacagaagagtcac

Downstream sequence

cccaggttcacgccattctcctgcctcagcctcccgagtagctgggactacaggcgcccgccaccgcgcccggctaattttttgtatttttagtagagac