VISDB Viral Integration Site DataBase

VIS ID

TVIS10009696

Fusion event

HBV-CNTNAP2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

156

Orient

+

Integrated sequence

CCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAAC| |ATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACT

Chromosome

chr7

Cytoband

q36.1

Reference genome

Start

End

148106864/148409772 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-218-5p ; hsa-mir-99b-5p ; hsa-mir-4444 ; hsa-mir-6079 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4428 ; hsa-mir-571 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u

Nearest miRNA

hsa-mir-10399/Upstream/1031651; hsa-mir-153-2/Downstream/2828649;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/70016, chr7-CpG: 200/Downstream/288566

Nearest cancer related gene

CNTNAP2(TSG, No orient, 0)

Upstream sequence

taacccctaaccctaaccctaccctaacccaaccctaacccaaccctaactctagccctagccctagccctagccctaagccctaagccctaagcctaac

Downstream sequence

tgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgaggcgggcggatcacaaggtcaggagatcgagaccatcttggctaacacggtga