Basic Information
VIS ID
TVIS10009698
Fusion event
HBV-LOC100128317 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2417
Orient
+
Integrated sequence
TCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCG| |TCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTT
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
81277437/81648121 (Hg38)
End
81277437/81648121 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC100128317
Nearest miRNA
hsa-mir-10525/Upstream/5732852; hsa-mir-10399/Downstream/10555894;
Nearest TSS
ENST00000635602/Upstream/460331; ENST00000454066/Downstream/114875;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/36729, chr7-CpG: 161/Downstream/794584
Nearby gene
SEMA3C(-728770) ; HGF(+54007) ;
Upstream sequence
ATAGGGGGCACGTCCTTCCTGAGACACGACCTGATCAGCTGGATGGAATTCTCCCTTAACACCCTCCCACCAGCCCGCACTGCCTGTCCACCAGCCTCAC
Downstream sequence
acatgtcattttacatttgtctaaacccatagaatatataacaccaactatgaactctggtgtaaactatggactttgggaaattaggatgcgtcaatat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate