Basic Information
VIS ID
TVIS10009699
Fusion event
HBV-LINC00972 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
-
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
85074004/85444688 (Hg38)
End
85074004/85444688 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC00972
Nearest miRNA
hsa-mir-10525/Upstream/9529419; hsa-mir-10399/Downstream/6759327;
Nearest TSS
ENST00000635602/Upstream/23566; ENST00000422448/Downstream/30539;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/257762, chr7-CpG: 45/Downstream/1341616
Nearby gene
SEMA3D(-322757) ; GRM3(+1199226) ;
Upstream sequence
AGCTGtttctttctttctgttttttttttttgagatggagtctcgctctgtcgcccaggctggagtgcagtggcacgatctcagctcactgcaatctccg
Downstream sequence
tcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaTAATGGTGAAGCATAGTGTTTTCAAACCAAATTATTGGAAAACTATGGTTATCAGGAGCAATACAAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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