Basic Information
VIS ID
TVIS10009700
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
74
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAG| |TTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCA
Host Sequence
Chromosome
chr7
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
97445931/97816619 (Hg38)
End
97445931/97816619 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/1596863; hsa-mir-10399/Downstream/147039;
Nearest TSS
ENST00000635602/Upstream/82665; ENST00000493372/Downstream/38256;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/82913, chr7-CpG: 74/Downstream/55252
Nearby gene
TAC1(-76147) ; ASNS(+35498) ;
Nearest cancer related gene
TAC1(OG, -76147) ;
Upstream sequence
tctttctttctgttttttttttttgagatggagtctcgctctgtcgcccaggctggagtgcagtggcacgatctcagctcactgcaatctccgcctcccg
Downstream sequence
aattagccgggcgcggtggcgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacctgggaggcggagcttgcagtgagcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate