Basic Information
VIS ID
TVIS10009702
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
-
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
132693304/131681057 (Hg38)
End
132693304/131681057 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1204/Upstream/1672604; hsa-mir-10400/Downstream/1365424;
Nearest TSS
ENST00000518652/Upstream/370585; ENST00000520362/Downstream/223031;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/638554, chr8-CpG: 92/Downstream/222946
Nearby gene
ADCY8(-640469) ; EFR3A(+223052) ;
Upstream sequence
tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg
Downstream sequence
GCCTCTCAATTAATATAAATGGGCATTGCGGATGTACCTGCAGTACAAAGAGAACTTGCCAAAAACCTCTGGAGAGGAGTTAACCATGCAACAAAGAAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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