Basic Information
VIS ID
TVIS10009705
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
103
Orient
+
Integrated sequence
TCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTA| |CTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACA
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
61343206/60430647 (Hg38)
End
61343206/60430647 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/17534372; hsa-mir-10400/Downstream/1284141;
Nearest TSS
ENST00000518652/Upstream/16717; ENST00000481569/Downstream/78112;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/149011, chr8-CpG: 84/Downstream/85968
Nearby gene
CA8(-149252) ; RAB2A(+86263) ;
Upstream sequence
caaagaaataataagtgtttgaggtggtggtacatatcctaaataccctggtttgatcattacccattatatgcatgtatccatatatcatgtgtacccc
Downstream sequence
gcaagctccgcctcccaggttcacgccattctcctgcctcagcctcccgagtagctgggactacaggcgcccgccaccgcgcccggctaattttttgtat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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