Basic Information
VIS ID
TVIS10009709
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
66
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGT| |GGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACA
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
91558728/90546500 (Hg38)
End
91558728/90546500 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/10305027; hsa-mir-10400/Downstream/658985;
Nearest TSS
ENST00000518652/Upstream/324962; ENST00000519233/Downstream/59565;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/544462, chr8-CpG: 159/Downstream/98661
Nearby gene
LINC00534(-158541) ; TMEM64(+75495) ;
Upstream sequence
CTTCCAAAGCAGCCTTTCCTCCTTCAGCCACTGCCCGTCACATCACCGTATTATTTTATAAGATTCTTCTCATAACTTTGCTTTTTTTACTTATTTATTG
Downstream sequence
gcgcccgccaccgcgcccggctaattttttgtatttttagtagagacggggtttcaccgtgttagccaagatggtctcgatctcctgaccttgtgatccg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate