Basic Information
VIS ID
TVIS10009712
Fusion event
HBV-LOC105376214 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
32
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGA| |TCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCG
Host Sequence
Chromosome
chr9
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
111148036/108385756 (Hg38)
End
111148036/108385756 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
LOC105376214
Nearest miRNA
hsa-let-7a-1/Upstream/1784734; hsa-mir-12126/Downstream/660473;
Nearest TSS
ENST00000422679/Upstream/130936; ENST00000333999/Downstream/317336;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/668617, chr9-CpG: 67/Downstream/469284
Nearby gene
KLF4(-895989) ; ACTL7B(+468833) ;
Upstream sequence
AGTGCAGGCTCACATCCACTAAGATGTAACTGTGGTTGCCAACTTAGAGACTTTTATTTTAAAATTTCTGAAATTACAATCGTGAATTTTACGAAGCATT
Downstream sequence
tcacaaggtcaggagatcgagaccatcttggctaacacggtgaaaccccgtctctactaaaaatacaaaaaattagccgggcgcggtggcgggcgcctgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate