Basic Information
VIS ID
TVIS10009713
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
495
Orient
+
Integrated sequence
TATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCC| |TCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATT
Host Sequence
Chromosome
chr9
Cytoband
q31.3
Reference genome
End
111307339/108545059 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-let-7a-1/Upstream/1944037; hsa-mir-12126/Downstream/501170;
Nearby gene
KLF4(-1055292) ; ACTL7B(+309530) ;
Nearest cancer related gene
KLF4(OG, -1055292) ;
Upstream sequence
ccctcaccctcaccctcaccctcaccctcaccctaaccctaccctaacccctaacccctaacccctaacccctaacccttaaccctaaccctaaccctac
Downstream sequence
acccttctaacaatttccctgaacacccaggactcttgcaggctgccatgctttgcacattccattcctttcctggagaaagtctttcccatcttcgctt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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