AIF1L _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009715
Fusion event
HBV-AIF1L integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
64
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTG| |GTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAA
Host Sequence
Chromosome
chr9
Cytoband
q34.13
Reference genome
GRCh37/hg19
Start
133997413/131122026 (Hg38)
End
133997413/131122026 (Hg38)
Orient
-
Location type
UTR3
Target gene
AIF1L
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1229-3p
Nearest miRNA
hsa-let-7a-1/Upstream/495663; hsa-mir-126/Downstream/1823681;
Nearest TSS
ENST00000422679/Upstream/10624; ENST00000531584/Downstream/3535;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/25347, chr9-CpG: 55/Downstream/3371
Upstream sequence
GGAATATGGCTGAGCCATCATCCGTTCTatggttggatagatggatgcatgaatgggtggatggatgggtggatgggttgattggatggatgagagatgg
Downstream sequence
gtccaataggaaagtgagacccagacaatgacaatgagataaatgttaggAAGGGGGAGGTATGGGGTGACTTCCCTGCAGTCCTGGGGGCCTAGATGGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate