Basic Information
VIS ID
TVIS10009720
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
542
Orient
+
Integrated sequence
TTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCA| |AGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTA
Host Sequence
Chromosome
chr9
Cytoband
q13
Reference genome
GRCh37/hg19
Start
68488409/63892675 (Hg38)
End
68488409/63892675 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA9F
Nearest miRNA
hsa-mir-101-2/Upstream/22658840; hsa-let-7a-1/Downstream/6917300;
Nearest TSS
ENST00000422679/Upstream/78516; ENST00000615302/Downstream/476719;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/32613, chr9-CpG: 29/Downstream/128449
Nearby gene
FRG1JP(-34034) ; FRG1HP(+238132) ;
Upstream sequence
gggttaggattagggtaagggtaagggttatggttagggttttagggttagggttttagggttagggttaggggttaggggttagggttagggttagggt
Downstream sequence
GATTGGCTAGTGGTAAGTTAAACCATAACCTGTAGAACCACTGGGAACCATTGCTTGTCACCGGCCAGAAATCCACTGTTTGGAGGTGTGTGCTGGGAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate